Early onset of growth hormone deficiency in childhood
In patients with early onset of growth hormone deficiency in childhood, the ability to secrete growth hormone should be examined at the end of the growth phase.
This review is not necessary in patients with more than three pituitary hormone deficiencies, in patients with severe growth hormone deficiency due to a defined genetic cause, due to structural hypothalamic-pituitary abnormalities, Central nervous system or high-dose cerebral radiation therapy, or due to growth hormone deficiency following pituitary or hypothalamic disease, or pituitary or hypothalamic involvement, if the measurement of IGF-I (Insulin-like Growth Factor-I) is less than -2 SDS after a break of at least 4 weeks of growth hormone therapy.
Beginning of adult growth hormone deficiency
In adults, insulin tolerance testing is the most common diagnostic test. However, compared to the insulin tolerance test, these tests are less convincing for diagnosis.
Deficiency of growth hormone
Dose of 0.025-0.035 mg / kg of body weight per day or 0.7-1.0 mg / m² of body surface area per day
Children with intrauterine growth retardation (GAS)
Dose of 0.033-0.067 mg / kg of body weight per day or 1.0-2.0 mg / m² of body surface area per day.Buy norditropin online | norditropin for sale | norditropin
In the event of severe growth hormone deficiency (response <6 ng / ml following a stimulation test), further treatment according to the literature may be considered up to about 25 years of age.
Dose of 0.025-0.035 mg / kg of body weight per day or 0.7-1.0 mg / m² of body surface area per day.
The recommended dose is usually 0.035 mg / kg body weight per day until reaching the final size.
Subcutaneous injection is the recommended route of administration. Some studies have shown that a replacement of the im injection with sc injection leads to an acceleration of growth in one year. Moreover, an im injection causes a high, supraphysiological, but brief serum growth hormone level. The sc injection makes it possible to achieve more regular serum concentrations, better suited to the physiological values. During injection sc, the injection site must be changed between each injection, in order to avoid the appearance of lipoatrophy.
Duration of treatment: The duration of the treatment usually carried out continuously for several years depends on the evolution of the body size and the intended therapeutic objective.Buy norditropin online | norditropin for sale | norditropin